[BK21 Plus Seminar]
       
         
      ▶Subject: CNS-Mediated Control of Energy and Mental Homeostasis; Crosstalk between SF-1 and FoxO1 in the Ventromedial Hypothalamus
             
      
      ▶Speaker: Prof. Ki Woo Kim (Wonju College of Medicine, Yonsei University)

                                
      
      ▶Date: 4:00PM/Oct/30(Thu)/2014
              
        
      ▶Place: Auditorium(1F), Postech Biotech Center
             
      
             *Abctract
           Obesity, diabetes, and metabolic complications are growing concerns for public health and could lead to detrimental life-threating conditions. Accumulating evidence suggests that incidences of metabolic syndrome are closely associated with mental disorders such as anxiety and depression, and they share common pathways in the brain. Neurons whose activities are required for energy and psychiatric homeostasis are found in a number of hypothalamic nuclei. The ventral medial nucleus of the hypothalamus (VMH), among several hypothalamic nuclei, emerged recently as an important site for mediating body weight homeostasis and psychiatric behaviors. This lecture will be focused on the emerging homeostatic roles of the VMH, particularly highlighting the control of energy metabolism and psychiatric behaviors in the SF-1 neurons of the VMH. Furthermore, I will illustrate functional roles of transcription factors including SF-1 and FoxO1 and circulating factors such as insulin and leptin in the VMH. Finally, I will discuss the underlying molecular mechanisms responsible for the regulation of energy homeostasis and psychiatric behaviors in the VMH.

     

      ▶Inquiry: Prof. Sung Ho Ryu (279-2292)
          
      * This seminar will be given in English