[BK21 Plus Seminar]

▶Subject: Next generation drug delivery platform based on exosome engineering: potential and applications

▶Speaker: Chulhee Choi, M.D., Ph.D. (Professor, Department of Bio and Brain Engineering, KAIST)

▶Date: 5:00PM/Aug. 3(Thur.)/2017

▶Place: Auditorium(1F), Postech Biotech Center

▶Abctract
In this presentation, an opto-genetically engineered exosome system, named ‘exosomes for protein loading via optically reversible protein–protein interaction” (EXPLOR) that can deliver soluble proteins into the cytosol via controlled, reversible protein–protein interactions (PPI) will be introduced. By integrating a reversible PPI module controlled by blue light with the endogenous process of exosome biogenesis, cargo proteins can be loaded into newly generated exosomes. Treatment with protein-loaded EXPLORs was shown to significantly increase intracellular levels of cargo proteins and their function in recipient cells in both a time- and dose-dependent manner. Previously, it has been shown to delivery mCherry, Cre enzyme, Bax, and Super repressor IκB proteins as functional proteins in the target cells and in vivo. In this presentation, the results for follow-up studies will also be discussed.

▶Inquiry: Prof. Yong Song Gho (279-2345)

* This seminar will be given in Korean.
Please refrain from taking photos during seminars. *