[BK21 Plus Seminar] ▶Subject: Metabolic stress in HBV-induced hepatic disease development ▶Speaker: JaeHun Cheong, PH.D. (Pusan National University) ▶Date: 4:00PM/Dec. 22(Tue.)/2015 ▶Place: Auditorium(1F), Postech Biotech Center *Abctract Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and chronic hepatitis B virus (HBV) infection is the most common risk factor for HCC. The HBV proteins can induce oncogenic effects or synergy effects with the hyperproliferative response on transformation into HCC. Cyclic-AMP-responsive-element-binding protein H (CREBH) activated by ER stress is liver-specific expressed ER-resident transmembrane bZIP transcription factors. Here, we addressed the roles of CREBH activated by ER stress on HBV-induced hepatic cell proliferation. We confirmed CREBH activation by ER stress and showed CREBH activation by HBx-induced ER stress. CREBH activated by HBx increased the expressions of AP-1 target genes through c-Jun induction. Under pathological conditions such as liver damage or liver regeneration, activated CREBH may play important roles on hepatic inflammation and cell proliferation as insulin receptor with dual-function under the conditions. We showed that CREBH activated by HBx interacted with HBx protein, leading to synergic effect on the expressions of AP-1 target genes and proliferation of heptocellular carcinoma cells and mouse primary hepatocytes. In conclusion, in HBV-infected hepatic cells or chronic hepatitis B patients, CREBH may induce proliferation of hepatic cells in cooperation with HBx, resulting in HCC. ▶Inquiry: Prof. Jang, Sung Key (279-2298) * This seminar will be given in Korean. please refrain from taking photos during seminars. *