[BK21 Plus Seminar]
          
            
         ▶Subject: CARP-1 Signaling: A Novel Means for Development of Anti-Cancer Strategies
                    
         ▶Speaker: Prof. Arun Kumar Rishi
                        (Department of Oncology, Wayne State University)
                                 
         ▶Date: 13:00PM/May/21(Thur.)/2015
                 
         ▶Place: Life Science Bldg. #104

                     
                *Abctract
             CARP-1/CCAR1 is a cytoplasmic phospho-protein that is a regulator of cell growth and apoptosis signaling. Our goal is to develop novel, safer, and effective anti-cancer therapies on the basis of cell growth and survival inhibiting functions of CARP-1. CARP-1 interacts with key cell signaling transducers including the Anaphase Promoting Complex/Cyclosome subunit (APC)-2 and the nuclear factor kappa B regulator NEMO/IKKgamma. A cell-permeable, multifunctional peptide, termed TAT-N-A, that has APC-2 and NEMO-binding CARP-1 epitopes, inhibits growth of cancer cells. By conducting the high-throughput screening of chemical libraries, we next identified novel, small molecule inhibitors of CARP-1:APC-2 interaction. These compounds, called CARP-1 Functional Mimetics (CFMs), inhibit growth of a variety of cancer cells including the drug-resistant cancer cells without affecting growth of immortalized mammary epithelial cells. CFMs suppress cancer cell growth in part by stimulating CARP-1 levels and promoting apoptosis. CFMs impact biological properties of cancer cells by inhibiting their movement, invasion, and growth in soft-agar. A nanolipid formulation (NLF) of CFM-4, our lead compound, enhances its bio-availability. Oral administration of CFM-4 NLF suppresses growth of Non-Small Cell Lung (NSCLC) and Triple Negative Breast Cancer (TNBC) xenografts. In conclusion identification of CARP-1 and CFMs provide proof-of-concept to facilitate development of strategies to combat a variety of cancers including the drug-resistant cancers.

         ▶Inquiry: Prof.Yoo, Joo-Yeon (279-2346)
                
          
          * This seminar will be given in English.
 please refrain from taking photos during seminars. *