[BK21 Plus Seminar]
              
                 
             ▶Subject: Synapse weakening pathway: A new conceptual understanding of Alzheimer’s disease
               
             ▶Speaker: Prof. Kei (Kwangwook) Cho

               (Centre for Synaptic Plasticity, School of Clinical Sciences, University of Bristol)
                      
             ▶Date: 3:00PM/Nov.10(Tue.)/2015
                
             ▶Place: Life Science Bldg. #104
               
                     *Abctract
                   The cognitive deficits that characterise Alzheimer’s disease (AD) are critically linked to progressive neurodegeneration and synaptic dysfunction in the brain. Previous research into key risk factors for the onset of AD focused heavily on abnormal protein aggregations and regulation of pathogenes. However, a gene-centric view of AD manifestation has generated limited translation into the understanding of pathophysiology, at least in relation to progressive decline of synaptic function. Evidence from a variety of experimental models demonstrates that aberrantly enhanced downscaling of synaptic transmission is at the heart of AD pathology; driving AMPA receptor endocytosis and synapse elimination. Inhibition of synapse weakening signals prevents neurotoxic effects from AD pathogens. Therefore, we highlight the importance of ‘Synaptic Biology’ in AD pathophysiology and discuss a new conceptual understanding of the roles of functional plasticity in AD and its links to therapeutic intervention.

                 
            ▶Inquiry: Prof. Sang Ki Park (279-2349) 
        
               * This seminar will be given in English.
           please refrain from taking photos during seminars. *