[2015 Fall Life Sciences & IBB Regular Seminar]
            
              
          ▶Subject: Peroxiredoxin as Antioxidant, Local Regulator, and Sensor of H2O2
            
          ▶Speaker: Prof. Sue-Goo Rhee

            (Yonsei Biomedical Research Institute, Yonsei University College of Medicine)
                    
          ▶Date: 4:00PM/Oct./23(Fri.)/2015
             
          ▶Place: Auditorium(1F), Postech Biotech Center
            
                  *Abctract
                Peroxiredoxins (Prxs) constitute a major family of peroxidases, and mammalian cells express six Prx isoforms (PrxI to PrxVI). Cells produce H2O2 at various intracellular locations where it can serve as a signaling molecule. Given that Prxs are abundant and possess a structure that renders the cysteine (Cys) residue at the active site highly sensitive to oxidation by H2O2, the signaling function of this oxidant requires extensive and highly localized regulation. Recent findings on the reversible regulation of PrxI through phosphorylation at the centrosome and the hyperoxidation of the Cys at the active site of PrxIII in mitochondria are here described as examples of such local H2O2 regulation. Moreover, their high affinity for and sensitivity to oxidation by H2O2 confer on Prxs the ability to serve as sensors and transducers of H2O2 signaling through transfer of their oxidation state to bound effector proteins.

                 
         ▶Inquiry: Prof. Sung Ho Ryu (279-2292) 
     
            * This seminar will be given in English.
        please refrain from taking photos during seminars. *