[2014 Fall Life Sciences & IBB Regular Seminar]
  
    
 ▶Subject: Shaping the Eukaryotic transcriptome with Chromatin and ncRNA
 
 ▶Speaker: Prof. Stephen Buratowski (Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School)
         
 ▶Date: 4:00PM/Sept./19(Fri)/2014
        
 ▶Place: Auditorium(1F), Postech Biotech Center
        
         *Abctract
       My lab studies the events that make up the RNA polymerase II transcription cycle. Each step - initiation, elongation, and termination - is carefully orchestrated and coordinated with other processes such as mRNA processing and chromatin modification. A major component of this coupling is the C-terminal domain (CTD) on the Rpb1 subunit of RNA polymerase II. The changing CTD phosphorylation pattern serves to mark the position of the transcription complex relative to the transcription start site. Various factors bind to specific phosphorylation configurations, resulting in sequential recruitment of mRNA processing and chromatin modifying enzymes at the appropriate times.
I will present our recent work addressing the mechanisms by which the CTD phosphorylation patterns changes during transcription, how various factors recognize these patterns, and what the downstream effects are on gene expression. In particular, we have found that a great deal of non-coding transcription in yeast affects expression of nearby coding gene, not through any activities of the RNAs themselves, but by changing the chromatin modification patterns at promoters that are overlapped by non-coding transcription.

  ▶Inquiry: Prof. Roh,Tae-Young (279-2350)
       
   * This seminar will be given in English