[2014 Fall Life Sciences & IBB Regular Seminar]
        
          
       ▶Subject: HIF-2α and the zinc-ZIP8-MTF1 axis in osteoarthritis
       
       ▶Speaker: Jang-Soo Chun, Ph.D.

                        (School of Life Sciences, Gwangju Institute of Science and Technology)
               
       ▶Date: 4:00PM/Nov./28(Fri)/2014
              
       ▶Place: Room 401, Chemistry Building
              
               *Abctract
            Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction. Biophysical and biochemical factors, including mechanical stress and pro-inflammatory cytokines, respectively, are responsible for the activation of catabolic pathways and initiation of OA cartilage destruction. Activation of certain biochemical pathways in chondrocytes?unique resident cells that synthesize cartilage-specific extracellular matrix (ECM) components as well as various catabolic and anabolic factors?eventually leads to cartilage destruction. Among the articular chondrocyte biochemical pathways important in this context are those leading to the production of matrix metalloproteinases (MMPs) and ADAMTS (a disintegrin and metalloproteinases with thrombospondin motifs), which are involved in the degradation of the ECM. However, the molecular pathogenic mechanisms of OA are not understood in sufficient detail to allow the development of effective therapeutic targets for OA treatment. This talk will introduce our recent findings of novel catabolic and anabolic factors regulating OA, including hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis.

       ▶Inquiry: Prof. Sin-Hyeog Im (279-2356)
             
         * This seminar will be given in English