[Jigok Lecture Series] ▶Subject: Necroptosis : an alternative cell death program ▶Speaker: Prof. You-Sun Kim (Department of Biochemistry and Department of Biomedical Sciences, Ajou University School of Medicine) ▶Date: 4:30PM/June. 2(Thu.)/2016 ▶Place: Auditorium(1F), Postech Biotech Center *Abctract Programmed cell death (PCD) is a ubiquitous process that occurs in all multicellular eukaryotes and is necessary to sustain tissue homeostasis and health. Programmed necrotic cell death is distinguished from its apoptotic counterpart in that it is not characterized by the activation of caspases; unlike apoptosis, programmed necrosis results in plasma membrane rupture, thus spilling the contents of the cell and triggering the activation of the immune system and inflammation. Recently, receptor-interacting protein kinase-3 (RIP3, or RIPK3) was found as an essential part of the cellular machinery that executes the programmed necrotic cell death pathway, which is activated in response to death receptor ligands and other types of cellular stress. Here we discuss findings, including our own recent data, which show that RIP3 protein expression is absent in many cancer cell lines. The recent data suggests that the lack of RIP3 expression in a majority of these deficient cell lines is due to methylation-dependent silencing, which limits the responses of these cells to pro-necrotic stimuli. Importantly, RIP3 expression may be restored in many cancer cells through the use of hypomethylating agents, such as decitabine. The potential implications of loss of RIP3 expression in cancer are explored, along with possible consequences for chemotherapeutic response. ▶Inquiry: Prof. Yoo, Joo-Yeon (279-2346) * This seminar will be given in English. please refrain from taking photos during seminars. *