생명과학과·I-Bio 특별세미나 안내

[Announcement on Life Sciences·I-Bio Special Seminar (4) ]
          
            
         ▶Subject: Inference of chromatin 3D structures from whole genomic context
         
         ▶Speaker: Misook Ha, Ph.D.
                          (Research Staff Member, Samsung Advanced Institute of Technology
                            / Visiting Scholar National Heart Lung Blood Institute, NIH))
                 
         ▶Date: 13:00~14:00 /Dec./12(Fri)/2014
                
         ▶Place: Auditorium(1F), POSTECH Biotech Center
                
                 *Abctract
             Designing personalized medical treatments relies heavily upon the ability to extract the genetic and medical information stored in a human genomic DNA. As DNA sequencing procedures become routine, new understanding of the genome will enable us to translate a DNA sequence into genetic and medical information. Human genomes are packaged in a nucleus, forming chromatin 3D structure that determines the activity of the underlying genes, and the genetic elements regulating other genes. By integrating various chromatin modification marks, we decipher chromatin signatures for prediction and controlling the gene expression and traits. We measure nucleosome dynamics across the ESC genome and find that DNA sequence composition is an important factor for formation and dynamics of chromatin structure. We find the DNA sequence features specific to chromatin 3D structures and develop a computational prediction method predicting chromatin structural modifications based on whole genome sequence in a high resolution. We demonstrate that DNA sequence encodes information about the 3D structure and that we can infer the information from a primary genome sequence. Our 1bp-resolution map of the chromatin structure encoded in the whole genomic context is a valuable start point for understanding the genetic and medical information encoded in a genome

      ?▶Inquiry: Life Sciences Tel: 279-2721, 8181