[BK21 Plus Seminar] ▶Subject: Genes involved in the effects of dietary restriction in mice ▶Speaker: Isao Shimokawa, MD, Ph.D. (Department of Pathology, Nagasaki University School of Medicine and Graduate School of Biomedical Sciences) ▶Date: 3:00 PM/Mar. 10(Thu.)/2016 ▶Place: Conference room(#179), Postech Biotech Center *Abctract We have sought genes required for the anti-aging effects of dietary restriction (DR) for many years. Our recent studies using Foxo1- and Foxo3-heterzygotic knockout (+/?) mice have shown that anti-neoplastic and life-extending effects of DR are mediated by Foxo1 and Foxo3 separately. However, in the ad libitum feeding (AL) conditions, Foxo1+/? and Foxo3+/? mice displayed little difference compared to wild-type mice. In our study using neuropeptide Y (Npy)-knockout mice, the effects of DR were mostly abrogated in Npy?/? mice, indicating an essential role for Npy in the effects of DR. In the AL conditions, Npy?/? mice showed a few symptoms or signs; rather, deletion of Npy gene produced some benefits against aging-related metabolic disorders. Our DR studies in knockout mice found some genes involved in the effect of DR, one of those showing pleiotropic roles in the regulation of aging depending on nutritional conditions. Keywords: Dietary Restriction; Foxo; Neuropeptide Y; Peiotropy ▶Inquiry: Prof. Lee, Seung-Jae(279-2351) * This seminar will be given in English. please refrain from taking photos during seminars. *