▶Subject: Mechanisms and physiology of the Golgi complex and intracellular trafficking

▶Speaker: Seung-Yeol Park, Ph.D (Division of Rheumatology, Immunology and Allergy, Department of Medicine,
Brigham and Women’s H ospit al and H ar va r d Medi cal School)

▶Date: 4:00PM/Sept. 3(Mon.)/ 2018

▶Place: Auditorium(1F), Postech Biotech Center

▶Abctract
The Golgi complex plays a central role in the sorting of cargoes in secretory pathway. While the altered structure of Golgi complex was found in a variety of diseases, the mechanisms of how this organelle is regulated are less well understood. Here we show that polarized Golgi transport regulated by the small GTPase Cdc42 promotes cellular transformation. Moreover, CDC42 regulates bidirectional transport within the Golgi complex by targeting the dual functions of Coat protein I (COPI) in cargo sorting and carrier formation. CDC42 also directly imparts membrane curvature to promote Golgi tubule formation. Further exploring how intracellular transport and tumorigenesis could be linked, we have uncovered a new angle. We recently discovered that a ciliary protein, intraflagellar transport 20 (IFT20), mediates the ability of Ror2 signaling to promote tumor invasion. IFT20 acts in this capacity by promoting Golgi ribbon formation, which is needed for the formation of invadopodia, as well as promoting anterograde Golgi transport. Altogether, these findings advance an understanding of how polarized Golgi transport contributes to tumorigenesis, as the rapid growth and division of tumors is predicted to require enhanced secretion.

▶Contact: Department of Life Sciences (Tel. 279-2721)

* This seminar will be given in English.
please refrain from taking photos during seminars. *